Immunohistochemical Detection of CD3 Antigen (Pan T Marker) in Canine Lymphomas
نویسندگان
چکیده
منابع مشابه
Immunohistochemical detection of P-glycoprotein in various subtypes of canine lymphomas.
Combination chemiotherapy is the current standard of care for dogs with lymphoma. Multidrug resistance is one of the most important factors contributing to the efficacy of chemiotherapy. The major protein responsible for this phenomenon is P-glycoprotein. Little is known about P-glycoprotein expression in particular subtypes of lymphomas. The aim of the study was evaluation of P-glycoprotein ex...
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متن کاملCytoplasmic Expression of the CD3 Antigen as a Diagnostic Marker for Immature T-CeIl Malignancies
The expression of cytoplasmic CD3 (CyCD3) was analyzed in 45 leukemias, five thymus cell samples. five peripheral blood (PB) samples, and ten cell lines. All T cell acute lymphoblastic leukemias (T-ALL) that did not express surface membrane CD3 (SmCD3) appeared to express CyCD3. Furthermore, the majority of SmCD3 T-ALL also expressed CyCD3. Analogous results were obtained with thymus cell sampl...
متن کاملImmunohistochemical expression study of proapoptotic BH3-only protein bad in canine nonneoplastic tissues and canine lymphomas.
The BH3-only protein Bad is a proapoptotic Bcl-2 family member that acts as a sensitizer in intrinsic apoptosis by inactivating antiapoptotic members through heterodimer formation. Bad has been shown to contribute to tumorigenesis, including lymphoma formation in humans and mice, through alteration in expression or functional status. Here, its immunohistochemical expression was analyzed in cani...
متن کاملCytoplasmic expression of the CD3 antigen as a diagnostic marker for immature T-cell malignancies.
The expression of cytoplasmic CD3 (CyCD3) was analyzed in 45 leukemias, five thymus cell samples, five peripheral blood (PB) samples, and ten cell lines. All T cell acute lymphoblastic leukemias (T-ALL) that did not express surface membrane CD3 (SmCD3) appeared to express CyCD3. Furthermore, the majority of SmCD3+ T-ALL also expressed CyCD3. Analogous results were obtained with thymus cell samp...
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ژورنال
عنوان ژورنال: Journal of Veterinary Diagnostic Investigation
سال: 1993
ISSN: 1040-6387,1943-4936
DOI: 10.1177/104063879300500420